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Human CellExp Progranulin, Human Recombinant
id: LP-4738-10

Human CellExp Progranulin, Human Recombinant


Synonyms and alternative names: Acrogranin, Paragranulin, Granulin-1, Acrogranin, Paragranulin, Granulin-1

Description: Regulator of cell growth, wound healing, and tumorigenesis. Human CellExp Progranulin, Human Recombinant; Background Information: Progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6.0 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Progranulin Human Recombinant fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 593 amino acids and having a molecular mass of 88.0 kDa. The Progranulin is purified by standard chromatographic techniques.

Host organism: Human
Source: HEK 293 cells
Recombinant: Yes
NCBI Gene Symbol: GRN
Accession #: P28799
Purity by SDS-PAGE: ≥90%
Biological activity: Measured by chemotaxis using THP-1 cells.
Molecular weight: 88.0 kDa
Concentration: 0.5 mg/ml
Appearance: Liquid
Physical form: Sterile filtered clear solution in PBS

Shipping: Gel pack
Storage: -20°C
Shelf life: 12 months

Research Use Only.