NR-160

SMILES: O=C(NO)C1=CC=C(C=C1)CN(C(=O)C=2C=CC=CC2C(F)(F)F)CC3=NN=NN3CC=4C=CC=CC4
Formula: C25H21F3N6O3

Description: NR-160

Purity: 0.98
CAS#: 2484895-50-1
Molecular Weight: 510.47
Bioactivity: NR-160 is an inhibitor of histone deacetylase 6 (HDAC6
IC50= 0.03 ?M).1It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 ?M, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 ?M). It enhances cytotoxicity induced by bortezomib in HL-60 cells, as well as cytotoxicity induced by epirubicin or daunorubicin in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.

For research use only.