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Recombinant Murine Noggin Protein
id: LP-PROTP97466-1

Labprice Recombinant Murine Noggin Protein

BosterBio


Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains.

"category: Recombinant Proteins"
"gene name: Nog"
"contents: Protein concentration verified by UV Spectroscopy and/or SDS-PAGE gel."
"uniprot_id: P97466"
"form: Solid
white powder or thin/invisible film"
"purification: NA"
"applications: Cell Culture"
"subcellular_localization: Secreted."
"source: E. Coli"

Store in -20°c for long term storage. After reconstitution, store in 4°c for short term usage within a few days. Avoid freeze-thaw cycles.

this product is available in other size, Various Sizes, please contact us for more information.


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