Rociletinib hydrobromide

Description: Rociletinib hydrobromide (CO-1686 hydrobromide) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.

CAS number: 1446700-26-0
Purity: 98.04
Formula: C27H29BrF3N7O3
Solubility: DMSO : ? 59 mg/mL|H2O : < 0.1 mg/mL
SMILES: C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O.[H]Br
Molecular Weight: 636.46
Applications: Cancer-Kinase/protease

4°C (Powder, sealed storage, away from moisture)