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Anti-Phospho-CBL-(Y774) antibody
id: LP-STJ117892

Labprice Anti-Phospho-CBL-(Y774) antibody

St John's Laboratory


Description: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

Clonality: Polyclonal
Host: Rabbit
Conjugation: Unconjugated
Applications: WB
Reactivity: Human
Formulation: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification: Affinity purification
Clone: NA
Concentration: NA
Gene: CBL
Immunogen: A synthetic phosphorylated peptide around Y774 of human CBL (NP_005179.2).



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