Labprice PDCD5 Antibody

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Description: PDCD5 Antibody: Programmed cell death 5 (PDCD5), a human apoptosis-related protein, is thought to play an early and universal role in apoptosis. PDCD5 is widely expressed and is upregulated in cells undergoing apoptosis, where it translocates rapidly from the cytoplasm to the nucleus. PDCD5 has a compact core structure of low flexibility with two mobile alpha-helices at N-terminal and a flexible unstructured C-terminal region. The charged residues are crucial for the ability of apoptosis-promoting and cell translocation of the protein. PDCD5 can facilitate apoptosis and enhance TAJ/TROY-induced paraptosis-like cell death. PDCD5 may play a dual role in the Tip60 pathway. It interacts with Tip60 and functions as a Tip60 co-activator to promote apoptosis. The nucleotide polymorphisms in the 5'-upstream region of PDCD5 affect promoter activity and the susceptibility of a Chinese population to develop chronic myelogenous leukemia and may represent a novel tumor suppressor gene influencing lung cancer.

Research area: Neuroscience
Host species: Rabbit
Species reactivity: Human, Mouse, Rat
Homology: Predicted species reactivity based on immunogen sequence: Bovine: (100%)
Immunogen: PDCD5 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human PDCD5.
The immunogen is located within the first 50 amino acids of PDCD5.
Tested Applications: E, WB, ICC
Applications: PDCD5 antibody can be used for detection of PDCD5 by Western blot at 2.5 μ
g/mL. Antibody can also be used for immunocytochemistry starting at 5 μ
g/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested.
Specificity: N/A
Positive control 1: Cat. No. 1205 - Jurkat Cell Lysate
Positive control 2: Cat. No. 17-005 - Jurkat Cell Slide
Positive control 3: N/A
Positive control 4: N/A
Positive control 5: N/A
Positive control 6: N/A
Predicted molecular weight: Predicted: 14 kDa
Observed: 21 kDa
MW explanation: N/A
Validation: N/A
Isoforms: N/A
Purification: PDCD5 Antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical state: Liquid
Buffer: PDCD5 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
NCBI official symbol: STK39
Accession #: CAG33215
Protein GI #: 115430252
NCBI gene ID#: 27347
NCBI official full name: serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
NCBI organism: Homo sapiens
SWISSPROT #: Q9UEW8

PDCD5 antibody can be stored at 4˚
C for three months and -20˚
C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Optimal dilutions for each application to be determined by the researcher.