Labprice TTBK2 Antibody

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Description: TTBK2 Antibody: Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.

Research area: Neuroscience
Host species: Rabbit
Species reactivity: Human
Homology: Predicted species reactivity based on immunogen sequence: Mouse: (88%)
Immunogen: TTBK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human TTBK2.
The immunogen is located within the last 50 amino acids of TTBK2.
Tested Applications: E, IHC-P
Applications: TTBK2 antibody can be used for detection of TTBK2 by immunohistochemistry at 5 μ
g/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificity: TTBK2 antibody is human specific. At least four isoforms of TTBK2 are known to exist
this antibody will detect only the two largest isoforms.
Positive control 1: N/A
Positive control 2: N/A
Positive control 3: N/A
Positive control 4: N/A
Positive control 5: N/A
Positive control 6: N/A
Predicted molecular weight: N/A
MW explanation: N/A
Validation: N/A
Isoforms: N/A
Purification: TTBK2 Antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical state: Liquid
Buffer: TTBK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
NCBI official symbol: TTBK2
Accession #: AAH71556
Protein GI #: 47940064
NCBI gene ID#: 146057
NCBI official full name: tau tubulin kinase 2
NCBI organism: Homo sapiens
SWISSPROT #: Q6IQ55

TTBK2 antibody can be stored at 4˚
C for three months and -20˚
C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Optimal dilutions for each application to be determined by the researcher.