Labprice CDIP Antibody

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Description: CDIP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death; loss of its functions contributes to the development of most cancers. CDIP is a novel pro-apoptotic target gene whose inhibition abrogates p53-mediated apoptotic responses. Overexpression of CDIP induced apoptosis in transfected cells while siRNA suppression of caspase-8 mRNA blocked this CDIP-induced apoptosis, indicating that the CDIP-dependent apoptosis pathway proceeds through extrinsic cell death pathway. CDIP may thus represent a novel target for drug design to maximize p53 response and sensitize tumor cells to cancer therapy. Multiple isoforms of CDIP are known to exist.

Research area: Apoptosis
Host species: Rabbit
Species reactivity: Human, Mouse
Homology: Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (100%)
Immunogen: CDIP antibody was raised against a 19 amino acid synthetic peptide near the center of human CDIP.
The immunogen is located within amino acids 70 - 120 of CDIP.
Tested Applications: E, WB, IHC-P, IF
Applications: CDIP antibody can be used for detection of CDIP by Western blot at 0.25 - 0.5 μ
g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ
g/mL. For immunofluorescence start at 20 μ
g/mL.
Antibody validated: Western Blot in human samples
Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Specificity: N/A
Positive control 1: Cat. No. 1303 - Human Brain Tissue Lysate
Positive control 2: N/A
Positive control 3: N/A
Positive control 4: N/A
Positive control 5: N/A
Positive control 6: N/A
Predicted molecular weight: N/A
MW explanation: N/A
Validation: N/A
Isoforms: N/A
Purification: CDIP Antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical state: Liquid
Buffer: CDIP Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
NCBI official symbol: CDIP1
Accession #: NP_037531
Protein GI #: 118344450
NCBI gene ID#: 29965
NCBI official full name: cell death inducing p53 target 1
NCBI organism: Homo sapiens
SWISSPROT #: Q9H305

CDIP antibody can be stored at 4˚
C for three months and -20˚
C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Optimal dilutions for each application to be determined by the researcher.