Labprice LZTS2 Antibody

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Description: LZTS2 Antibody: The leucine zipper putative tumor suppressor 2 (LZTS2, also known as LAPSER1), a member of the LZTS family, is a negative regulator of the Wnt signaling pathway. It represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. LZTS2 is involved in cytokinesis and regulates katanin-mediated microtubule severing and release from the centrosome. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. LZTS2 is highly expressed in testis and prostate, but it is deleted in multiple cancers, including prostate tumors, suggesting that LZTS2 acts as a potential tumor suppressor.

Research area: Cancer, Cell Cycle
Host species: Rabbit
Species reactivity: Human
Homology: Predicted species reactivity based on immunogen sequence: Bovine: (94%), Mouse: (88%), Rat: (82%)
Immunogen: LZTS2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human LZTS2.
The immunogen is located within amino acids 570 - 620 of LZTS2.
Tested Applications: E, IHC-P
Applications: LZTS2 antibody can be used for detection of LZTS2 by immunohistochemistry at 5 μ
g/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested.
Specificity: LZTS2 antibody is predicted to not cross-react with other LZTS family members.
Positive control 1: N/A
Positive control 2: N/A
Positive control 3: N/A
Positive control 4: N/A
Positive control 5: N/A
Positive control 6: N/A
Predicted molecular weight: N/A
MW explanation: N/A
Validation: N/A
Isoforms: N/A
Purification: LZTS2 Antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical state: Liquid
Buffer: LZTS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
NCBI official symbol: LZTS2
Accession #: NP_115805
Protein GI #: 45331215
NCBI gene ID#: 84445
NCBI official full name: leucine zipper, putative tumor suppressor 2
NCBI organism: Homo sapiens
SWISSPROT #: Q9BRK4

LZTS2 antibody can be stored at 4˚
C for three months and -20˚
C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Optimal dilutions for each application to be determined by the researcher.