Labprice Human BMP-4 (E. coli , Animal Free) Recombinant Protein

Description: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor.  The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa.

Gene name: BMP-4 (E. coli , Animal Free)
Host: E. coli
Label: None
Applications: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml.
Purity: ? 98% by SDS-PAGE gel and HPLC analyses
Additives/Stabilizer: None
Form: lyophilized
MW: 23,9 kDa
Length (aa): 106
Protein Sequence: KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
NCBI GeneID: 652
Accession Number Protein: NP_001193
Accession Numberm RNA: NM_001202
Uniprot: P12644
Chromosomal location: 14q22-q23

For research use only.