Labprice CD47 Recombinant Protein

Description: Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

Tested Applications: E, WB
Applications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.7 kDa. The protein migrates as 33-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Predicted Molecular Weight: 15.7 kDa
Physical state: Lyophilized
Buffer: PBS, pH7.4
Concentration: N/A
NCBI official symbol: N/A
Accession #: XP_006521874.1
Protein GI: N/A
NCBI gene ID#: N/A
NCBI official full name:
NCBI organism: N/A
Peptide sequence: N/A
SWISSPROT #: N/A
Background Reference 1: Lindberg F.P., et al., 1993, J. Cell Biol. 123:485-496.
Background Reference 2: Latour S., et al., 2001, J. Immunol. 167:2547-2554.
Background Reference 3: Piccio L., et al., 2005, Blood 105:2421-2427.
Background Reference 4: N/A
Background Reference 5: N/A
Source: HEK293 cells
Species: Mouse
By Source: Human Cells
By Species: Mouse
Fusion tag: His Tag
Sequence: Gln 19 - Lys 140
Biology activity: N/A
Purity: >90% as determined by SDS-PAGE.

Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.