Labprice HGF Recombinant Protein

Description: Hepatocyte growth factor (HGF) is a paracrine cellular growth, motility and morphogenic factor. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. In addition, HGF has been implicated in a variety of cancers, including of the lungs, pancreas, thyroid, colon, and breast.

Tested Applications: E, WB
Applications: This protein carries a polyhistidine tag at the C-terminus. The mature form of HGF is a disulfide-linked heterodimer composed of proteolytically cleaved ? and ? chain. The protein has a calculated MW of 81.6 kDa (? chain 53.7 kDa and ? chain 27.9 kDa). Th
Predicted Molecular Weight: 81.6 kDa (53.7 kDa|27.9 kDa)
Physical state: Lyophilized
Buffer: PBS, pH7.4
Concentration: N/A
NCBI official symbol: N/A
Accession #: N/A
Protein GI: N/A
NCBI gene ID#: N/A
NCBI official full name: N/A
NCBI organism: N/A
Peptide sequence: N/A
SWISSPROT #: N/A
Background Reference 1: Johnson M, et al. Hepatology. 1993. 17(6):1052-61.
Background Reference 2: Bottaro DP, et al. Science. 1991. 251(4995):802-4.
Background Reference 3: Stamos J, et al. EMBO J. 2004. 23(12):2325-35.
Background Reference 4: N/A
Background Reference 5: N/A
Source: HEK293 cells
Species: Human
By Source: Human Cells
By Species: Human
Fusion tag: His Tag
Sequence: Gln 32 - Ser 728
Biology activity: N/A
Purity: >90% as determined by SDS-PAGE.

Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.